human KCNH4 shRNA silencing AAV

Name
AAV-h-KCNH4-shRNA

Cat No
shAAV-212699

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human KCNH4.

shAAV-212699

AAV-h-KCNH4-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human KCNH4 (potassium voltage-gated channel subfamily H member 4). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

BEC2; ELK1; Kv12.3

Description (Vector)

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. The gene is brain-specific, and located in the neocortex and the striatum. It may be involved in cellular excitability of restricted neurons in the central nervous system.

Gene ID

23415

Gene Name (Vector)

potassium voltage-gated channel subfamily H member 4

Gene Symbol

KCNH4

HGNC ID

HGNC:6253

ORF Size (aa)

3051

ORF Size (bp)

3051 bp

RefSeq ID

NM_012285

RefSeq Synonyms

NM_012285, BC140292,

Species

human

UniGene ID

Hs.304081

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.