human KCNE1 shRNA silencing AAV

Name
AAV-h-KCNE1-shRNA

Cat No
shAAV-212683

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human KCNE1.

shAAV-212683

AAV-h-KCNE1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human KCNE1 (potassium voltage-gated channel subfamily E regulatory subunit 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ISK; JLNS; JLNS2; LQT2/5; LQT5; MinK

Description (Vector)

The product of this gene belongs to the potassium channel KCNE family. Potassium ion channels are essential to many cellular functions and show a high degree of diversity, varying in their electrophysiologic and pharmacologic properties. This gene encodes a transmembrane protein known to associate with the product of the KVLQT1 gene to form the delayed rectifier potassium channel. Mutation in this gene are associated with both Jervell and Lange-Nielsen and Romano-Ward forms of long-QT syndrome. Alternatively spliced transcript variants encoding the same protein have been identified.

Gene ID

3753

Gene Name (Vector)

potassium voltage-gated channel subfamily E regulatory subunit 1

Gene Symbol

KCNE1

HGNC ID

HGNC:6240

ORF Size (aa)

390

RefSeq ID

NM_000219

RefSeq Synonyms

NM_001270405, NM_001270404, NM_001270403, NM_001270402, NM_001127670, NM_001127669, NM_001127668, NM_000219, BC046224, BC036452,

Species

human

UniGene ID

Hs.121495

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.