human JUN shRNA silencing AAV

Name
AAV-h-JUN-shRNA

Cat No
shAAV-212606

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human JUN.

shAAV-212606

AAV-h-JUN-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human JUN (Jun proto-oncogene, AP-1 transcription factor subunit). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

activator protein 1; AP1; AP-1; c-Jun; enhancer-binding protein AP1; Jun activation domain binding protein; jun oncogene; p39; proto-oncogene c-Jun; transcription factor AP-1; v-jun avian sarcoma virus 17 oncogene homolog; v-jun sarcoma virus 17 oncogene homolog

Description (eCommerce)

c-Jun is a transcription factor that heterodimerizes with FOS to form the activator protein 1 (AP-1) transcription factor. The JUN gene is the putative transforming gene of avian sarcoma virus 17.

Description (Vector)

JUN is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. JUN is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies.

Gene ID

3725

Gene Name (eCommerce)

Jun proto-oncogene, AP-1 transcription factor subunit

Gene Name (Vector)

Jun proto-oncogene, AP-1 transcription factor subunit

Gene Symbol

JUN

HGNC ID

HGNC:6204

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

996

ORF Size (bp)

996 bp

Protein Name (eCommerce)

Transcription factor AP-1

RefSeq ID

NM_002228

RefSeq Synonyms

NM_002228, BC068522, BC006175,

Research Areas

Aging,Angiogenesis,Apoptosis,Autophagy,B-cell Receptor Signaling,BDNF Signaling,Breast Cancer,Cancer,Cardiac Hypertrophy,Cardiology,Cardiovascular,CD40 Signaling,CD95/FAS Signaling,Cell Cycle,Colorectal Cancer,DNA Damage/Repair,DNA Replication,EGFR Signaling,Estrogen Signaling,Fc Receptor Signaling,FGF Signaling,GnRH Signaling,HGF Signaling,Host-Virus Interactions,Hypoxia,IGF-1 Signaling,Immunology,Innate Immunity,Insulin Signaling,Interleukin Signaling,Kidney Cancer,Lung Cancer,MAPK Signaling,Neurobiology,Neurodevelopment,NF-kB Signaling,NGF Signaling,Notch Signaling,PDGF Signaling,Prolactin Signaling,Prostate Cancer,RAC1 Signaling,RANKL-RANK Signaling,Rho Signaling,RNA Binding,SCF-KIT Signaling,Signal Transduction,T-cell Receptor Signaling,TGF-beta Signaling,TNF Signaling,Toll-like Receptor Signaling,TPO Signaling,Transcription Factor/Regulator,TSH Signaling,Tumor Suppressors/Oncoproteins,TWEAK Signaling,Viral Carcinogenesis,Wnt Signaling

Research Areas (Faceted)

cancer,cardiovascular,cell_biology,cell_cycle,developmental_biology,genetics,immunology,infectious_disease,neurobiology,signal_transduction,stem_cell_biology,transcription_translation

Species

human

Target Sentence

c-Jun is a transcription factor that heterodimerizes with FOS to form the activator protein 1 (AP-1) transcription factor. The JUN gene is the putative transforming gene of avian sarcoma virus 17.

UniGene ID

Hs.714791

UniProt ID (eCommerce)

P05412

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.