human JRK shRNA silencing AAV

Name
AAV-h-JRK-shRNA

Cat No
shAAV-212594

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human JRK.

shAAV-212594

AAV-h-JRK-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human JRK (Jrk helix-turn-helix protein). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

jerky; JH8

Description (Vector)

JRK is the human homolog of the mouse jerky gene. The encoded protein has similarity to several nuclear regulatory proteins, including centromere protein B, suggesting that it might function as a DNA-binding protein. Insertional inactivation of this gene in transgenic mice resulted in epileptic seizures. Childhood Absence Epilepsy (CAE) has been mapped to the same chromosomal location (8q24.3) as this gene, making this gene a strong candidate for CAE. Two transcript variants encoding different isoforms have been found for this gene.

Gene ID

8629

Gene Name (Vector)

Jrk helix-turn-helix protein

Gene Symbol

JRK

HGNC ID

HGNC:6199

ORF Size (aa)

1707

ORF Size (bp)

1707 bp

RefSeq ID

NM_003724

RefSeq Synonyms

NM_003724, NM_001279352, NM_001077527, BC043351,

Species

human

UniGene ID

Hs.683465

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.