human ITGA2B shRNA silencing AAV

Name
AAV-h-ITGA2B-shRNA

Cat No
shAAV-212475

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human ITGA2B.

shAAV-212475

AAV-h-ITGA2B-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ITGA2B (integrin subunit alpha 2b). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

BDPLT16; BDPLT2; CD41; CD41B; GP2B; GPIIb; GT; GTA; HPA3; PPP1R93

Description (Vector)

ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.

Gene ID

3674

Gene Name (Vector)

integrin subunit alpha 2b

Gene Symbol

ITGA2B

HGNC ID

HGNC:6138

ORF Size (aa)

3120

ORF Size (bp)

3120 bp

RefSeq ID

NM_000419

RefSeq Synonyms

NM_000419, BC126442, BC117443,

Species

human

UniGene ID

Hs.411312

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.