human INVS shRNA silencing AAV

Name
AAV-h-INVS-shRNA

Cat No
shAAV-212333

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human INVS.

shAAV-212333

AAV-h-INVS-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human INVS (inversin). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

INV; NPH2; NPHP2

Description (Vector)

INVS encodes a protein containing multiple ankyrin domains and two IQ calmodulin-binding domains. The encoded protein may function in renal tubular development and function, and in left-right axis determination. This protein interacts with nephrocystin and infers a connection between primary cilia function and left-right axis determination. A similar protein in mice interacts with calmodulin. Mutations in this gene have been associated with nephronophthisis type 2. Multiple transcript variants encoding distinct isoforms have been identified for this gene.

Gene ID

27130

Gene Name (Vector)

inversin

Gene Symbol

INVS

HGNC ID

HGNC:17870

ORF Size (aa)

3198

ORF Size (bp)

3198 bp

RefSeq ID

NM_014425

RefSeq Synonyms

NM_183245, NM_014425, NM_001318382, NM_001318381, BC112351, BC111761,

Species

human

UniGene ID

Hs.558477

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.