human INTS8 shRNA silencing AAV

Name 
AAV-h-INTS8-shRNA
Cat No 
shAAV-212329
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human INTS8.

shAAV-212329
AAV-h-INTS8-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human INTS8 (integrator complex subunit 8). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
C8orf52; INT8; integrator complex subunit 8; protein kaonashi-1
Description (eCommerce)
The epitope recognized by IHC-00415 maps to a region between residues 200 and 250 of human INT8 using the numbering given in SwissProt entry Q75QN2 (GeneID 55656).
Description (Vector)
INTS8 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 (PubMed 16239144)).(supplied by OMIM, Mar 2008)
Gene ID
55656
Gene Name (eCommerce)
integrator complex subunit 8
Gene Name (Vector)
integrator complex subunit 8
Gene Symbol
INTS8
HGNC ID
HGNC:26048
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2988
ORF Size (bp)
2988 bp
Protein Name (eCommerce)
Integrator complex subunit 8
RefSeq ID
NM_017864
RefSeq Synonyms
NM_017864, BC136754,
Research Areas
RNA Processing
Research Areas (Faceted)
cell_biology,genetics,transcription_translation
Species
human
Target Sentence
The epitope recognized by IHC-00415 maps to a region between residues 200 and 250 of human INT8 using the numbering given in SwissProt entry Q75QN2 (GeneID 55656).
UniGene ID
Hs.521693
UniProt ID (eCommerce)
Q75QN2

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.