human ING1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human ING1.
shAAV-212260
AAV-h-ING1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human ING1 (inhibitor of growth family member 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
growth inhibitor ING1; growth inhibitory protein ING1; inhibitor of growth protein 1; p24ING1c; p33; p33ING1; p33ING1b; p47; p47ING1a; tumor suppressor ING1
Description (eCommerce)
Inhibitor of growth protein 1 (ING1) cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. It is implicated as a tumor suppressor gene [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9UK53].
Description (Vector)
ING1 encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.
Gene ID
3621
Gene Name (eCommerce)
inhibitor of growth family member 1
Gene Name (Vector)
inhibitor of growth family member 1
Gene Symbol
ING1
HGNC ID
HGNC:6062
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
840
ORF Size (bp)
840 bp
Protein Name (eCommerce)
Inhibitor of growth protein 1
RefSeq ID
NM_005537
RefSeq Synonyms
NM_198219, NM_198218, NM_198217, NM_005537, NM_001267728, BC093944, BC093942,
Research Areas
Apoptosis,Autophagy,Cancer,Cell Cycle,Tumor Suppressors/Oncoproteins,Zinc-finger
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,genetics
Species
human
Target Sentence
Inhibitor of growth protein 1 (ING1) cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. It is implicated as a tumor suppressor gene [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9UK53].
UniGene ID
Hs.709738
UniProt ID (eCommerce)
Q9UK53
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.