human INCENP shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human INCENP.
shAAV-212258
AAV-h-INCENP-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human INCENP (inner centromere protein). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
binds and activates aurora-B and -C in vivo and in vitro; chromosomal passenger protein; inner centromere protein; inner centromere protein antigens 135/155kDa; inner centromere protein INCENP
Description (eCommerce)
INCENP (inner centromere protein) is a component of the chromosomal passenger complex (CPC) which is a group of proteins that localizes to the centromere during specific stages of the cell cycle. The CPC is key regulator of mitosis that functions in spindle assembly, chromosome alignment, and segregation. INCENP contains a coiled-coil domain that interacts with microtubules and is required for the spindle-assembly checkpoint.
Description (Vector)
In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and 'passenger,' or transiently interacting, proteins (reviewed by Choo, 1997). The constitutive proteins include CENPA (centromere protein A; MIM 117139), CENPB (MIM 117140), CENPC1 (MIM 117141), and CENPD (MIM 117142). The term 'passenger proteins' encompasses a broad collection of proteins that localize to the centromere during specific stages of the cell cycle (Earnshaw and Mackay, 1994 (PubMed 8088460)). These include CENPE (MIM 117143); MCAK (MIM 604538); KID (MIM 603213); cytoplasmic dynein (e.g., MIM 600112); CliPs (e.g., MIM 179838); and CENPF/mitosin (MIM 600236). The inner centromere proteins (INCENPs) (Earnshaw and Cooke, 1991 (PubMed 1860899)), the initial members of the passenger protein group, display a broad localization along chromosomes in the early stages of mitosis but gradually become concentrated at centromeres as the cell cycle progresses into mid-metaphase. During telophase, the proteins are located within the midbody in the intercellular bridge, where they are discarded after cytokinesis (Cutts et al., 1999 (PubMed 10369859)).(supplied by OMIM, Mar 2008)
Gene ID
3619
Gene Name (eCommerce)
inner centromere protein
Gene Name (Vector)
inner centromere protein
Gene Symbol
INCENP
HGNC ID
HGNC:6058
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2757
ORF Size (bp)
2757 bp
Protein Name (eCommerce)
Inner centromere protein
RefSeq ID
NM_020238
RefSeq Synonyms
NM_020238, NM_001040694, BC098576,
Research Areas
Cell Cycle,Cell Division,Cytoskeleton,PLK1 Signaling,Signal Transduction
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,signal_transduction
Species
human
Target Sentence
INCENP (inner centromere protein) is a component of the chromosomal passenger complex (CPC) which is a group of proteins that localizes to the centromere during specific stages of the cell cycle. The CPC is key regulator of mitosis that functions in spindle assembly, chromosome alignment, and segregation. INCENP contains a coiled-coil domain that interacts with microtubules and is required for the spindle-assembly checkpoint.
UniGene ID
Hs.142179
UniProt ID (eCommerce)
Q9NQS7
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.