human IL19 shRNA silencing AAV

Cat. No: shAAV-212088

Availability: 6-8 weeks

Name: AAV-h-IL19-shRNA

This is an AAV expressing shRNA for silencing of Human IL19.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: IL19
Gene Name: interleukin 19
Gene ID: 29949
Gene Synonyms: IL-10C; MDA1; NG.1; ZMDA1
ORF Size: 645 bp
RefSeq#: NM_013371
Gene Description: IL19 is a cytokine that belongs to the IL10 cytokine subfamily. This cytokine is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described.
UniGene ID: Hs.661017
HGNC ID: HGNC:5990