human IKBKG shRNA silencing AAV

Name 
AAV-h-IKBKG-shRNA
Cat No 
shAAV-212012
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human IKBKG.

shAAV-212012
AAV-h-IKBKG-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human IKBKG (inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
50
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
AMCBX1; FIP-3; FIP3; Fip3p; IKK-gamma; IKKAP1; IKKG; IMD33; IP; IP1; IP2; IPD2; NEMO; ZC2HC9
Description (Vector)
IKBKG encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome.
Gene ID
8517
Gene Name (Vector)
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
Gene Symbol
IKBKG
HGNC ID
HGNC:5961
ORF Size (aa)
1260
ORF Size (bp)
1260 bp
RefSeq ID
NM_003639
RefSeq Synonyms
NM_003639, NM_001321397, NM_001321396, NM_001145255, NM_001099857, NM_001099856, BC050612, BC046922, BC012114, BC000299,
Species
human
UniGene ID
Hs.43505

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.