human HTR2B shRNA silencing AAV

Name
AAV-h-HTR2B-shRNA

Cat No
shAAV-211694

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human HTR2B.

shAAV-211694

AAV-h-HTR2B-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human HTR2B (5-hydroxytryptamine receptor 2B). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

5-HT(2B); 5-HT-2B; 5-HT2B

Description (Vector)

HTR2B encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved.

Gene ID

3357

Gene Name (Vector)

5-hydroxytryptamine receptor 2B

Gene Symbol

HTR2B

HGNC ID

HGNC:5294

ORF Size (aa)

1446

ORF Size (bp)

1446 bp

RefSeq ID

NM_000867

RefSeq Synonyms

NM_001320758, NM_000867, BC063123,

Species

human

UniGene ID

Hs.421649

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.