human HSD17B4 shRNA silencing AAV

Name 
AAV-h-HSD17B4-shRNA
Cat No 
shAAV-211578
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human HSD17B4.

shAAV-211578
AAV-h-HSD17B4-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
17beta-estradiol dehydrogenase type IV; 17-beta-HSD 4; 17-beta-HSD IV; 17-beta-hydroxysteroid dehydrogenase 4; 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase; beta-hydroxyacyl dehydrogenase; beta-keto-reductase; D-3-hydroxyacyl-CoA dehydratase; D-bifunctional protein; D-bifunctional protein, peroxisomal; DBP; epididymis secretory sperm binding protein; hydroxysteroid dehydrogenase 4; MFE-2; MPF-2; multifunctional protein 2; peroxisomal multifunctional enzyme type 2; peroxisomal multifunctional protein 2; PRLTS1; SDR8C1; short chain dehydrogenase/reductase family 8C member 1
Description (eCommerce)
HSD17B4 is a bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids.It catalyzes the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P51659].
Description (Vector)
HSD17B4 is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. It also acts as a catalyst for the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). An apparent pseudogene of this gene is present on chromosome 8.
Gene ID
3295
Gene Name (eCommerce)
hydroxysteroid 17-beta dehydrogenase 4
Gene Name (Vector)
hydroxysteroid 17-beta dehydrogenase 4
Gene Symbol
HSD17B4
HGNC ID
HGNC:5213
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2211
ORF Size (bp)
2211 bp
Protein Name (eCommerce)
Peroxisomal multifunctional enzyme type 2
RefSeq ID
NM_000414
RefSeq Synonyms
NM_001292028, NM_001292027, NM_001199292, NM_001199291, NM_000414, BC003098,
Research Areas
Cancer,Metabolism/Metabolic Process,Prostate Cancer
Research Areas (Faceted)
cancer,cell_biology,metabolism
Species
human
Target Sentence
HSD17B4 is a bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids.It catalyzes the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P51659].
UniGene ID
Hs.406861
UniProt ID (eCommerce)
P51659

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.