human HSD17B10 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human HSD17B10.
shAAV-211563
AAV-h-HSD17B10-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human HSD17B10 (hydroxysteroid 17-beta dehydrogenase 10). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
17-beta-HSD 10; 17-beta-hydroxysteroid dehydrogenase 10; 17b-HSD10; 2-methyl-3-hydroxybutyryl-CoA dehydrogenase; 3-hydroxy-2-methylbutyryl-CoA dehydrogenase; 3-hydroxyacyl-CoA dehydrogenase type II; 3-hydroxyacyl-CoA dehydrogenase type-2; ABAD; AB-binding alcohol dehydrogenase; amyloid-beta peptide binding alcohol dehydrogenase; CAMR; DUPXp11.22; endoplasmic reticulum-associated amyloid beta-peptide-binding protein; ERAB; HADH2; HCD2; HSD10MD; MHBD; mitochondrial ribonuclease P protein 2; Mitochondrial RNase P protein 2; mitochondrial RNase P subunit 2; MRPP2; MRX17; MRX31; MRXS10; SCHAD; SDR5C1; Short chain dehydrogenase/reductase family 5C member 1; short chain L-3-hydroxyacyl-CoA dehydrogenase type 2; short chain type dehydrogenase/reductase XH98G2; Short-chain type dehydrogenase/reductase XH98G2; Type II HADH
Description (eCommerce)
Mitochondrial dehydrogenase involved in pathways of fatty acid, branched-chain amino acid and steroid metabolism and acts as a dehydrogenase in mitochondrial fatty acid beta-oxidation. Also catalyzes the third step in the beta-oxidation cycle, and acts as a dehydrogenase in branched-chain amino acid catabolic pathway. [taken from NCBI Entrez Gene (Gene ID: 3028)].
Description (Vector)
HSD17B10 encodes 3-hydroxyacyl-CoA dehydrogenase type II, a member of the short-chain dehydrogenase/reductase superfamily. The gene product is a mitochondrial protein that catalyzes the oxidation of a wide variety of fatty acids, alcohols, and steroids. The protein has been implicated in the development of Alzheimer's disease, and mutations in the gene are the cause of 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency (MHBD). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.
Gene ID
3028
Gene Name (eCommerce)
hydroxysteroid 17-beta dehydrogenase 10
Gene Name (Vector)
hydroxysteroid 17-beta dehydrogenase 10
Gene Symbol
HSD17B10
HGNC ID
HGNC:4800
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
786
ORF Size (bp)
786 bp
Protein Name (eCommerce)
3-hydroxyacyl-CoA dehydrogenase type-2
RefSeq ID
NM_004493
RefSeq Synonyms
NM_004493, NM_001037811, BC008708, BC000372,
Research Areas
Aging,Alzheimer's Disease,Estrogen Signaling,Metabolism/Metabolic Process,Mitochondrion,Neurobiology,Neurodegeneration,RNA Processing,Signal Transduction
Research Areas (Faceted)
cell_biology,genetics,transcription_translation,metabolism,neurobiology,signal_transduction
Species
human
Target Sentence
Mitochondrial dehydrogenase involved in pathways of fatty acid, branched-chain amino acid and steroid metabolism and acts as a dehydrogenase in mitochondrial fatty acid beta-oxidation. Also catalyzes the third step in the beta-oxidation cycle, and acts as a dehydrogenase in branched-chain amino acid catabolic pathway. [taken from NCBI Entrez Gene (Gene ID: 3028)].
UniGene ID
Hs.171280
UniProt ID (eCommerce)
Q99714
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.