human HRAS shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human HRAS.
shAAV-211513
AAV-h-HRAS-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human HRAS (HRas proto-oncogene, GTPase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
C-BAS/HAS;C-HA-RAS1;c-has/bas p21 protein;C-H-RAS;c-Ki-ras;c-K-ras;c-ras-Ki-2 activated oncogene;CTLO;GTP- and GDP-binding peptide B;GTPase HRas;GTPase KRas;HAMSV;Ha-Ras;Ha-Ras1 proto-oncoprotein;Harvey rat sarcoma viral oncogene homolog;Harvey rat sarcoma viral oncoprotein;HRAS1;H-Ras-1;H-RASIDX;Ki-Ras;KRAS;K-Ras 2;KRAS2;p19 H-RasIDX protein;p21ras;Ras family small GTP binding protein H-Ras;RASH1;RASK2;transformation gene: oncogene HAMSV;transforming protein p21;v-Ha-ras Harvey rat sarcoma viral oncogene homolog
Description (eCommerce)
H-Ras belongs to the Ras oncogene family, whose members bind GDP/GTP and possess intrinsic GTPase activity. They function in a variety of signal transduction pathways. H-Ras is involved primarily in regulating cell division. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. [taken from NCBI Entrez Gene (Gene ID: 3265)].
Description (Vector)
HRAS belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene.
Gene ID
3265
Gene Name (eCommerce)
HRas proto-oncogene, GTPase
Gene Name (Vector)
HRas proto-oncogene, GTPase
Gene Symbol
HRAS
HGNC ID
HGNC:5173
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
570
Protein Name (eCommerce)
GTPase HRas
RefSeq ID
NM_005343
RefSeq Synonyms
NM_176795, NM_005343, NM_001318054, NM_001130442, BC095471, BC006499,
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,cell_cycle,developmental_biology,genetics,transcription_translation,immunology,infectious_disease,neurobiology,signal_transduction,stem_cell_biology
Species
human
Target Sentence
H-Ras belongs to the Ras oncogene family, whose members bind GDP/GTP and possess intrinsic GTPase activity. They function in a variety of signal transduction pathways. H-Ras is involved primarily in regulating cell division. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. [taken from NCBI Entrez Gene (Gene ID: 3265)].
UniGene ID
Hs.37003
UniProt ID (eCommerce)
P01112
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.