human HNRNPM shRNA silencing AAV

Name 
AAV-h-HNRNPM-shRNA
Cat No 
shAAV-211383
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human HNRNPM.

shAAV-211383
AAV-h-HNRNPM-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human HNRNPM (heterogeneous nuclear ribonucleoprotein M). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CEA receptor; CEAR; heterogeneous nuclear ribonucleoprotein M; heterogenous nuclear ribonucleoprotein M4; hnRNA-binding protein M4; hnRNP M; HNRNPM4; HNRPM; HNRPM4; HTGR1; N-acetylglucosamine receptor 1; NAGR1
Description (eCommerce)
The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties.
Description (Vector)
HNRNPM belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs. This protein also constitutes a monomer of the N-acetylglucosamine-specific receptor which is postulated to trigger selective recycling of immature GlcNAc-bearing thyroglobulin molecules. Alternative splicing results in multiple transcript variants.
Gene ID
4670
Gene Name (eCommerce)
heterogeneous nuclear ribonucleoprotein M
Gene Name (Vector)
heterogeneous nuclear ribonucleoprotein M
Gene Symbol
HNRNPM
HGNC ID
HGNC:5046
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2193
ORF Size (bp)
2193 bp
Protein Name (eCommerce)
Heterogeneous nuclear ribonucleoprotein M
RefSeq ID
NM_005968
RefSeq Synonyms
NM_031203, NM_005968, NM_001297418, BC019580, BC000138,
Research Areas
Gene Expression,Immunology,Metabolism/Metabolic Process,mRNA Processing,mRNA Splicing,RNA Binding,RNA Processing,Spliceosome,Transport
Research Areas (Faceted)
genetics,transcription_translation,immunology,metabolism,genetics,transcription_translation,cell_biology
Species
human
Target Sentence
The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties.
UniGene ID
Hs.666214
UniProt ID (eCommerce)
P52272

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.