human HNMT shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human HNMT.
shAAV-211331
AAV-h-HNMT-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human HNMT (histamine N-methyltransferase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
HMT; HNMT-S1; HNMT-S2; MRT51
Description (Vector)
In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene.
Gene ID
3176
Gene Name (Vector)
histamine N-methyltransferase
Gene Symbol
HNMT
HGNC ID
HGNC:5028
ORF Size (aa)
879
ORF Size (bp)
879 bp
RefSeq ID
NM_006895
RefSeq Synonyms
NM_006895, NM_001024075, NM_001024074, BC020677,
Species
human
UniGene ID
Hs.42151
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.