human HNF4A shRNA silencing AAV

Name
AAV-h-HNF4A-shRNA

Cat No
shAAV-211327

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human HNF4A.

shAAV-211327

AAV-h-HNF4A-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human HNF4A (hepatocyte nuclear factor 4 alpha). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

FRTS4; HNF4; HNF4a7; HNF4a8; HNF4a9; HNF4alpha; MODY; MODY1; NR2A1; NR2A21; TCF; TCF14

Description (Vector)

HNF4A is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms.

Gene ID

3172

Gene Name (Vector)

hepatocyte nuclear factor 4 alpha

Gene Symbol

HNF4A

HGNC ID

HGNC:5024

ORF Size (aa)

1254

ORF Size (bp)

1254 bp

RefSeq ID

NM_000457

RefSeq Synonyms

NM_178850, NM_178849, NM_175914, NM_001287184, NM_001287183, NM_001287182, NM_001258355, NM_001030004, NM_001030003, NM_000457, BC137540, BC137539,

Species

human

UniGene ID

Hs.116462

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.