human HLA-DPB1 shRNA silencing AAV

Name
AAV-h-HLA-DPB1-shRNA

Cat No
shAAV-211218

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human HLA-DPB1.

shAAV-211218

AAV-h-HLA-DPB1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human HLA-DPB1 (major histocompatibility complex, class II, DP beta 1). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

DPB1; HLA-DP; HLA-DP1B; HLA-DPB

Description (Vector)

HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.

Gene ID

3115

Gene Name (Vector)

major histocompatibility complex, class II, DP beta 1

Gene Symbol

HLA-DPB1

HGNC ID

HGNC:4940

ORF Size (aa)

774

ORF Size (bp)

774 bp

RefSeq ID

NM_002121

RefSeq Synonyms

NM_002121, BC015000, BC013184, BC007963,

Species

human

UniGene ID

Hs.485130

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.