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human HLA-DPB1 Over-expression AAV

Name 
AAV-h-HLA-DPB1
Cat No 
AAV-211217
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human HLA-DPB1.

AAV-211217
AAV-h-HLA-DPB1

Ready-to-use AAV expressing Human HLA-DPB1 (major histocompatibility complex, class II, DP beta 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
DPB1; HLA-DP; HLA-DP1B; HLA-DPB
Description (Vector)
HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.
Gene ID
3115
Gene Name (Vector)
major histocompatibility complex, class II, DP beta 1
Gene Symbol
HLA-DPB1
HGNC ID
HGNC:4940
ORF Size (aa)
774
ORF Size (bp)
774 bp
RefSeq ID
NM_002121
RefSeq Synonyms
NM_002121, BC015000, BC013184, BC007963,
Species
human
UniGene ID
Hs.485130

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.