human HK1 shRNA silencing AAV

Name 
AAV-h-HK1-shRNA
Cat No 
shAAV-211203
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human HK1.

shAAV-211203
AAV-h-HK1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human HK1 (hexokinase 1). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
brain form hexokinase; glycolytic enzyme; hexokinase; hexokinase IR; hexokinase type I; hexokinase-1; HK; HK I; HK1-ta; HK1-tb; HK1-tc; HKD; HKI; HMSNR; HXK1; RP79
Description (eCommerce)
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Hexokinase 1 is a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria [taken from NCBI Entrez Gene (Gene ID: 3098)].
Description (Vector)
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene results in five transcript variants which encode different isoforms, some of which are tissue-specific. Each isoform has a distinct N-terminus; the remainder of the protein is identical among all the isoforms. A sixth transcript variant has been described, but due to the presence of several stop codons, it is not thought to encode a protein.
Gene ID
3098
Gene Name (eCommerce)
hexokinase 1
Gene Name (Vector)
hexokinase 1
Gene Symbol
HK1
HGNC ID
HGNC:4922
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2754
ORF Size (bp)
2754 bp
Protein Name (eCommerce)
Hexokinase-1
RefSeq ID
NM_033498
RefSeq Synonyms
NM_033500, NM_033498, NM_033497, NM_033496, NM_001322367, NM_001322366, NM_001322365, NM_001322364, NM_000188, BC008730,
Research Areas
HIF-1 Signaling,Insulin Signaling,Metabolism/Metabolic Process,Mitochondrion,Neurobiology,Neurodegeneration,Neurodevelopment,Signal Transduction
Research Areas (Faceted)
cell_biology,developmental_biology,metabolism,neurobiology,signal_transduction
Species
human
Target Sentence
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Hexokinase 1 is a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria [taken from NCBI Entrez Gene (Gene ID: 3098)].
UniGene ID
Hs.370365
UniProt ID (eCommerce)
P19367

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.