human HIP1 shRNA silencing AAV

Name 
AAV-h-HIP1-shRNA
Cat No 
shAAV-211038
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human HIP1.

shAAV-211038
AAV-h-HIP1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human HIP1 (huntingtin interacting protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
HIP-1; HIP-I; huntingtin-interacting protein 1; huntingtin-interacting protein I; ILWEQ; SHON; SHONbeta; SHONgamma
Description (eCommerce)
The product of gene HIP1, Huntingtin-interacting protein 1, is a membrane-associated protein that functions in clathrin-mediated endocytosis and protein trafficking within the cell. The encoded protein, as its name would imply, binds to huntingtin protein in the brain and this interaction is lost in Huntington's disease [taken from NCBI Entrez Gene (Gene ID: 3092)].
Description (Vector)
The product of this gene is a membrane-associated protein that colocalizes with huntingtin. This protein has similarities to cytoskeleton proteins and its interaction with huntingtin is thought to play a functional role in the cell filament network. Loss of normal huntingtin-HIP1 interaction in Huntington disease may contribute to a defect in membrane-cytoskeletal integrity in the brain. This gene could help in the understanding of the normal function of huntingtin and also the pathogenesis of Huntington disease. It also has been implicated in the pathogenesis of hematopoietic malignancies. Two transcript variants encoding different isoforms have been found for this gene.
Gene ID
3092
Gene Name (eCommerce)
huntingtin interacting protein 1
Gene Name (Vector)
huntingtin interacting protein 1
Gene Symbol
HIP1
HGNC ID
HGNC:4913
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3114
ORF Size (bp)
3114 bp
Protein Name (eCommerce)
Huntingtin-interacting protein 1
RefSeq ID
NM_005338
RefSeq Synonyms
NM_005338, NM_001243198, BC110545,
Research Areas
Apoptosis,Cytoskeleton,EGFR Signaling,Golgi Apparatus,Huntington's Disease,Neurobiology,Neurodegeneration,Signal Transduction,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
The product of gene HIP1, Huntingtin-interacting protein 1, is a membrane-associated protein that functions in clathrin-mediated endocytosis and protein trafficking within the cell. The encoded protein, as its name would imply, binds to huntingtin protein in the brain and this interaction is lost in Huntington's disease [taken from NCBI Entrez Gene (Gene ID: 3092)].
UniGene ID
Hs.619089
UniProt ID (eCommerce)
O00291

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.