human HERPUD1 shRNA silencing AAV

Name
AAV-h-HERPUD1-shRNA

Cat No
shAAV-210958

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human HERPUD1.

shAAV-210958

AAV-h-HERPUD1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human HERPUD1 (homocysteine inducible ER protein with ubiquitin like domain 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

HERP; Mif1; SUP

Description (Vector)

The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response. This response includes the inhibition of translation to prevent further accumulation of unfolded proteins, the increased expression of proteins involved in polypeptide folding, known as the unfolded protein response (UPR), and the destruction of misfolded proteins by the ER-associated protein degradation (ERAD) system. This gene may play a role in both UPR and ERAD. Its expression is induced by UPR and it has an ER stress response element in its promoter region while the encoded protein has an N-terminal ubiquitin-like domain which may interact with the ERAD system. This protein has been shown to interact with presenilin proteins and to increase the level of amyloid-beta protein following its overexpression. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms. The full-length nature of all transcript variants has not been determined.

Gene ID

9709

Gene Name (Vector)

homocysteine inducible ER protein with ubiquitin like domain 1

Gene Symbol

HERPUD1

HGNC ID

HGNC:13744

ORF Size (aa)

699

RefSeq ID

NM_014685

RefSeq Synonyms

NM_014685, NM_001272103, NM_001010990, NM_001010989, BC032673, BC009739, BC008320, BC000086,

Species

human

UniGene ID

Hs.146393

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.