human HDAC8 shRNA silencing AAV

Name 
AAV-h-HDAC8-shRNA
Cat No 
shAAV-210894
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human HDAC8.

shAAV-210894
AAV-h-HDAC8-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human HDAC8 (histone deacetylase 8). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CDA07; CDLS5; HD8; HDACL1; MRXS6; RPD3; WTS
Description (Vector)
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
55869
Gene Name (Vector)
histone deacetylase 8
Gene Symbol
HDAC8
HGNC ID
HGNC:13315
ORF Size (aa)
1134
ORF Size (bp)
1134 bp
RefSeq ID
NM_018486
RefSeq Synonyms
NM_018486, NM_001166448, NM_001166422, NM_001166420, NM_001166419, NM_001166418, BC050433,
Species
human
UniGene ID
Hs.310536

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.