human GZMM shRNA silencing AAV

Name
AAV-h-GZMM-shRNA

Cat No
shAAV-210721

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human GZMM.

shAAV-210721

AAV-h-GZMM-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human GZMM (granzyme M). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

LMET1; MET1

Description (Vector)

Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These serine proteases are collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and the protein encoded by this gene, granzyme M. Two transcript variants encoding different isoforms have been found for this gene.

Gene ID

3004

Gene Name (Vector)

granzyme M

Gene Symbol

GZMM

HGNC ID

HGNC:4712

ORF Size (aa)

774

ORF Size (bp)

774 bp

RefSeq ID

NM_005317

RefSeq Synonyms

NM_005317, NM_001258351, BC025701,

Species

human

UniGene ID

Hs.465511

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.