human GZMK shRNA silencing AAV

Name
AAV-h-GZMK-shRNA

Cat No
shAAV-210720

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human GZMK.

shAAV-210720

AAV-h-GZMK-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human GZMK (granzyme K). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

TRYP2

Description (Vector)

GZMK product is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here lacks consensus sequences for N-glycosylation present in other granzymes.

Gene ID

3003

Gene Name (Vector)

granzyme K

Gene Symbol

GZMK

HGNC ID

HGNC:4711

ORF Size (aa)

795

ORF Size (bp)

795 bp

RefSeq ID

NM_002104

RefSeq Synonyms

NM_002104, BC035802,

Species

human

UniGene ID

Hs.277937

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.