human GUCY2F shRNA silencing AAV

Name
AAV-h-GUCY2F-shRNA

Cat No
shAAV-210693

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human GUCY2F.

shAAV-210693

AAV-h-GUCY2F-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human GUCY2F (guanylate cyclase 2F, retinal). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CYGF; GC-F; GUC2DL; GUC2F; RETGC-2; ROS-GC2

Description (Vector)

GUCY2F is a guanylyl cyclase found predominantly in photoreceptors in the retina. The encoded protein is thought to be involved in resynthesis of cGMP after light activation of the visual signal transduction cascade, allowing a return to the dark state. This protein is a single-pass type I membrane protein. Defects in this gene may be a cause of X-linked retinitis pigmentosa.

Gene ID

2986

Gene Name (Vector)

guanylate cyclase 2F, retinal

Gene Symbol

GUCY2F

HGNC ID

HGNC:4691

ORF Size (aa)

3327

ORF Size (bp)

3327 bp

RefSeq ID

NM_001522

RefSeq Synonyms

NM_001522, BC156674,

Species

human

UniGene ID

Hs.123074

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.