human GTF2H2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human GTF2H2.
shAAV-210642
AAV-h-GTF2H2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human GTF2H2 (general transcription factor IIH subunit 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
BTF2; BTF2P44; p44; T-BTF2P44; TFIIH
Description (Vector)
GTF2H2 is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. GTF2H2 is within the telomeric copy of the duplication. Deletion of this gene sometimes accompanies deletion of the neighboring SMN1 gene in spinal muscular atrophy (SMA) patients but it is unclear if deletion of this gene contributes to the SMA phenotype. GTF2H2 encodes the 44 kDa subunit of RNA polymerase II transcription initiation factor IIH which is involved in basal transcription and nucleotide excision repair. Transcript variants for this gene have been described, but their full length nature has not been determined. A second copy of this gene within the centromeric copy of the duplication has been described in the literature. It is reported to be different by either two or four base pairs; however, no sequence data is currently available for the centromeric copy of the gene.
Gene ID
2966
Gene Name (Vector)
general transcription factor IIH subunit 2
Gene Symbol
GTF2H2
HGNC ID
HGNC:4656
ORF Size (aa)
1185
ORF Size (bp)
1185 bp
RefSeq ID
NM_001515
RefSeq Synonyms
NM_001515, BC141603, BC140303,
Species
human
UniGene ID
Hs.655216
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.