human GRM1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human GRM1.
shAAV-210546
AAV-h-GRM1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human GRM1 (glutamate receptor, metabotropic 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
GPRC1A; GRM1A; mGlu1; MGLUR1; MGLUR1A;
Description (Vector)
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The canonical alpha isoform of the metabotropic glutamate receptor 1 gene is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. Alternative splicing results in multiple transcript variants encoding distinct isoforms; some of which may have distinct functions.
Gene ID
2911
Gene Name (Vector)
glutamate receptor, metabotropic 1
Gene Symbol
GRM1
HGNC ID
HGNC:4593
ORF Size (aa)
3582
ORF Size (bp)
3582 bp
RefSeq ID
NM_000838
RefSeq Synonyms
NM_001278067, NM_001278066, NM_001278065, NM_001278064, NM_001114329, NM_000838, BC136280, BC111844,
Species
human
UniGene ID
Hs.32945
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.