human GRIK3 shRNA silencing AAV

Name
AAV-h-GRIK3-shRNA

Cat No
shAAV-210516

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human GRIK3.

shAAV-210516

AAV-h-GRIK3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human GRIK3 (glutamate ionotropic receptor kainate type subunit 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

EAA5; GLR7; GluK3; GLUR7; GluR7a

Description (Vector)

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. It is not certain if the subunit encoded by this gene is subject to RNA editing as the other 2 family members (GRIK1 and GRIK2). A Ser310Ala polymorphism has been associated with schizophrenia, and there are conflicting reports of its association with the pathogenesis of delirium tremens in alcoholics.

Gene ID

2899

Gene Name (Vector)

glutamate ionotropic receptor kainate type subunit 3

Gene Symbol

GRIK3

HGNC ID

HGNC:4581

ORF Size (aa)

2760

ORF Size (bp)

2760 bp

RefSeq ID

NM_000831

RefSeq Synonyms

NM_000831, BC156721,

Species

human

UniGene ID

Hs.128848

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.