human GRIA1 shRNA silencing AAV

Name
AAV-h-GRIA1-shRNA

Cat No
shAAV-210505

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human GRIA1.

shAAV-210505

AAV-h-GRIA1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human GRIA1 (glutamate ionotropic receptor AMPA type subunit 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

GluA1; GLUH1; GLUR1; GLURA; HBGR1

Description (Vector)

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene ID

2890

Gene Name (Vector)

glutamate ionotropic receptor AMPA type subunit 1

Gene Symbol

GRIA1

HGNC ID

HGNC:4571

ORF Size (aa)

2721

ORF Size (bp)

2721 bp

RefSeq ID

NM_000827

RefSeq Synonyms

NM_001258023, NM_001258022, NM_001258021, NM_001258020, NM_001258019, NM_001114183, NM_000827, BC111734,

Species

human

UniGene ID

Hs.519693

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.