human GPER shRNA silencing AAV

Name
AAV-h-GPER-shRNA

Cat No
shAAV-210227

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human GPER1.

shAAV-210227

AAV-h-GPER-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human GPER1 (G protein-coupled estrogen receptor 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CEPR; CMKRL2; DRY12; FEG-1; GPCR-Br; GPER; GPR30; LERGU; LERGU2; LyGPR; mER

Description (Vector)

GPER is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein that localizes to the endoplasmic reticulum. The protein binds estrogen, resulting in intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. This protein therefore plays a role in the rapid nongenomic signaling events widely observed following stimulation of cells and tissues with estrogen. Alternate transcriptional splice variants which encode the same protein have been characterized.

Gene ID

2852

Gene Name (Vector)

G protein-coupled estrogen receptor 1

Gene Symbol

GPER1

HGNC ID

HGNC:4485

ORF Size (aa)

1224

ORF Size (bp)

1224 bp

RefSeq ID

NM_001505

RefSeq Synonyms

NM_001505, NM_001098201, NM_001039966, BC082766, BC011634,

Species

human

UniGene ID

Hs.20961

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.