human GNB3 shRNA silencing AAV

Name
AAV-h-GNB3-shRNA

Cat No
shAAV-210105

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human GNB3.

shAAV-210105

AAV-h-GNB3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human GNB3 (G protein subunit beta 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CSNB1H

Description (Vector)

Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity. This polymorphism is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Additional splice variants may exist for this gene, but they have not been fully described.

Gene ID

2784

Gene Name (Vector)

G protein subunit beta 3

Gene Symbol

GNB3

HGNC ID

HGNC:4400

ORF Size (aa)

894

ORF Size (bp)

894 bp

RefSeq ID

NM_002075

RefSeq Synonyms

NM_002075, NM_001297571, BC015920, BC002454, BC000115,

Species

human

UniGene ID

Hs.631657

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.