human GLRX shRNA silencing AAV

Name
AAV-h-GLRX-shRNA

Cat No
shAAV-209995

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human GLRX.

shAAV-209995

AAV-h-GLRX-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human GLRX (glutaredoxin). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

GRX; GRX1

Description (Vector)

GLRX encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer's disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified.

Gene ID

2745

Gene Name (Vector)

glutaredoxin

Gene Symbol

GLRX

HGNC ID

HGNC:4330

ORF Size (aa)

321

RefSeq ID

NM_002064

RefSeq Synonyms

NM_002064, NM_001243659, NM_001243658, NM_001118890, BC106075, BC010965, BC005304,

Species

human

UniGene ID

Hs.712696

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.