human GDNF shRNA silencing AAV

Name
AAV-h-GDNF-shRNA

Cat No
shAAV-209792

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human GDNF.

shAAV-209792

AAV-h-GDNF-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human GDNF (glial cell derived neurotrophic factor). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ATF; ATF1; ATF2; HFB1-GDNF; HSCR3

Description (Vector)

GDNF encodes a highly conserved neurotrophic factor. The recombinant form of this protein was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene may be associated with Hirschsprung disease.

Gene ID

2668

Gene Name (Vector)

glial cell derived neurotrophic factor

Gene Symbol

GDNF

HGNC ID

HGNC:4232

ORF Size (aa)

636

ORF Size (bp)

636 bp

RefSeq ID

NM_000514

RefSeq Synonyms

NM_199231, NM_001278098, NM_001190469, NM_001190468, NM_000514, BC128109, BC128108, BC069369, BC069119,

Species

human

UniGene ID

Hs.248114

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.