human GCM2 shRNA silencing AAV

Cat. No: shAAV-209748

Availability: 6-8 weeks

Name: AAV-h-GCM2-shRNA

This is an AAV expressing shRNA for silencing of Human GCM2.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: GCM2
Gene Name: glial cells missing homolog 2
Gene ID: 9247
Gene Synonyms: GCMB; hGCMb
ORF Size: 1521 bp
RefSeq#: NM_004752
Gene Description: GCM2 is a homolog of the Drosophila glial cells missing gene, which is thought to act as a binary switch between neuronal and glial cell determination. The protein encoded by this gene contains a conserved N-terminal GCM motif that has DNA-binding activity. The protein is a transcription factor that acts as a master regulator of parathyroid development. It has been suggested that this transcription factor might mediate the effect of calcium on parathyroid hormone expression and secretion in parathyroid cells. Mutations in this gene are associated with hypoparathyroidism.
UniGene ID: Hs.227098
HGNC ID: HGNC:4198