human GCK shRNA silencing AAV
Category: AAV > shRNA-Silencing
Cat. No: shAAV-209742
Availability:
6-8 weeks
Name:
AAV-h-GCK-shRNA
This is an AAV expressing shRNA for silencing of Human GCK.
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Product Info
- Knockdown
- shRNA screening service available, please inquire about this service or other options.
Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- U6
- Reporter
- eGFP (default), optional CFP, YFP, RFP, mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- GCK
- Gene Name
- glucokinase
- Gene ID
- 2645
- Gene Synonyms
- FGQTL3; GK; GLK; HHF3; HK4; HKIV; HXKP; LGLK; MODY2
- ORF Size
- 1398 bp
- RefSeq#
- NM_033507
- Gene Description
- Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).
- UniGene ID
- Hs.1270
- HGNC ID
- HGNC:4195
Related Products
Product | Cat No. |
---|---|
AAV-h-GCK | AAV-209742 |
AAV-m-GCK | AAV-259983 |
Ad-h-GCK | ADV-209742 |
Ad-m-GCK | ADV-259983 |
AAV-m-GCK-shRNA | shAAV-259983 |
Ad-h-GCK-shRNA | shADV-209742 |
Ad-m-GCK-shRNA | shADV-259983 |
Control Products
Product | Cat No. |
---|---|
AAV1-GFP-U6-shRNA | 7040 |
AAV2-GFP-U6-shRNA | 7041 |
AAV5-GFP-U6-shRNA | 7042 |
AAV6-GFP-U6-shRNA | 7043 |
AAV9-GFP-U6-shRNA | 7045 |
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