human GCHFR shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human GCHFR.
shAAV-209740
AAV-h-GCHFR-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human GCHFR (GTP cyclohydrolase I feedback regulator). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
GFRP; HsT16933; P35
Description (Vector)
GTP cyclohydrolase I feedback regulatory protein binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. The regulatory protein, GCHFR, consists of a homodimer. It is postulated that GCHFR may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide.
Gene ID
2644
Gene Name (Vector)
GTP cyclohydrolase I feedback regulator
Gene Symbol
GCHFR
HGNC ID
HGNC:4194
ORF Size (aa)
222
RefSeq ID
NM_005258
RefSeq Synonyms
NM_005258, BC143904, BC112264, BC112262,
Species
human
UniGene ID
Hs.631717
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.