human GCHFR shRNA silencing AAV

Cat. No: shAAV-209740

Availability: 6-8 weeks

Name: AAV-h-GCHFR-shRNA

This is an AAV expressing shRNA for silencing of Human GCHFR.

Request a Quote

Please enter your email address and we'll be in touch with more information:

Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: GCHFR
Gene Name: GTP cyclohydrolase I feedback regulator
Gene ID: 2644
Gene Synonyms: GFRP; HsT16933; P35
ORF Size: 222 bp
RefSeq#: NM_005258
Gene Description: GTP cyclohydrolase I feedback regulatory protein binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. The regulatory protein, GCHFR, consists of a homodimer. It is postulated that GCHFR may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide.
UniGene ID: Hs.631717
HGNC ID: HGNC:4194