human GAPDH shRNA silencing AAV

Name 
AAV-h-GAPDH-shRNA
Cat No 
shAAV-209631
Availability
Immediate
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human GAPDH.

shAAV-209631
AAV-h-GAPDH-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human GAPDH (glyceraldehyde-3-phosphate dehydrogenase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
aging-associated gene 9 protein; epididymis secretory sperm binding protein Li 162eP; G3PD; GAPD; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; HEL-S-162eP; OCAS, p38 component; Oct1 coactivator in S phase, 38 Kd component; peptidyl-cysteine S-nitrosylase GAPDH
Description (eCommerce)
In the process of carbohydrate metabolism, GAPDH (glyceraldehydes-3-phosphate dehydrogenase) catalyzes the oxidative phosphorylation of glyceraldehydes-3-phosphate to 1,3-diphosphoglycerate in the presence of nicotinamide adenine dinucleotide (NAD) and inorganic phosphate. In addition to its role in the oxidation of glucose, GAPDH has been shown to be involved in other cellular processes such as vesicle transport, DNA repair, DNA replication, cytoskeletal modulation, and tRNA export.
Description (Vector)
The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The enzyme exists as a tetramer of identical chains. Many pseudogenes similar to this locus are present in the human genome. Two transcript variants encoding different isoforms have been found for this gene.
Gene ID
2597
Gene Name (eCommerce)
glyceraldehyde-3-phosphate dehydrogenase
Gene Name (Vector)
glyceraldehyde-3-phosphate dehydrogenase
Gene Symbol
GAPDH
HGNC ID
HGNC:4141
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1008
Protein Name (eCommerce)
Glyceraldehyde-3-phosphate dehydrogenase
RefSeq ID
NM_002046
RefSeq Synonyms
NM_002046, NM_001289746, NM_001289745, NM_001256799, BC083511, BC029618, BC026907, BC025925, BC023632, BC013310, BC009081, BC004109, BC001601,
Research Areas
Alzheimer's Disease,Apoptosis,Breast Cancer,Cancer,Cytoskeleton,DNA Damage/Repair,HIF-1 Signaling,Metabolism/Metabolic Process,Neurobiology,Neurodegeneration,Neurodevelopment,Signal Transduction,Translational Control
Research Areas (Faceted)
cancer,cell_biology,developmental_biology,genetics,transcription_translation,metabolism,neurobiology,signal_transduction
Species
human
Target Sentence
In the process of carbohydrate metabolism, GAPDH (glyceraldehydes-3-phosphate dehydrogenase) catalyzes the oxidative phosphorylation of glyceraldehydes-3-phosphate to 1,3-diphosphoglycerate in the presence of nicotinamide adenine dinucleotide (NAD) and inorganic phosphate. In addition to its role in the oxidation of glucose, GAPDH has been shown to be involved in other cellular processes such as vesicle transport, DNA repair, DNA replication, cytoskeletal modulation, and tRNA export.
UniGene ID
Hs.592355
UniProt ID (eCommerce)
P04406

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.