human G6PD shRNA silencing AAV

Name
AAV-h-G6PD-shRNA

Cat No
shAAV-209484

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human G6PD.

shAAV-209484

AAV-h-G6PD-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human G6PD (glucose-6-phosphate dehydrogenase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

90

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

epididymis secretory sperm binding protein; G6PD; G6PD1; glucose-6-phosphate 1-dehydrogenase

Description (eCommerce)

Glucose-6-phosphate dehydrogenase (G6PD) is a cytosolic enzyme that catalyzes the conversion of glucose-6-phosphate into 6-phosphgluconolactone and maintains the levels of the electron donor, NADPH. G6PD is an x-linked housekeeping gene whose deficiency can result in neonatal jaundice, acute hemolysis, or chronic non-spherocytic hemolytic anemia.

Description (Vector)

G6PD encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two transcript variants encoding different isoforms have been found for this gene.

Gene ID

2539

Gene Name (eCommerce)

glucose-6-phosphate dehydrogenase

Gene Name (Vector)

glucose-6-phosphate dehydrogenase

Gene Symbol

G6PD

HGNC ID

HGNC:4057

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

1548

ORF Size (bp)

1548 bp

Protein Name (eCommerce)

Glucose-6-phosphate 1-dehydrogenase

RefSeq ID

NM_000402

RefSeq Synonyms

NM_001042351, NM_000402, BC000337,

Research Areas

Immunology,Metabolism/Metabolic Process,T-cell Receptor Signaling

Research Areas (Faceted)

cell_biology,immunology,metabolism,signal_transduction

Species

human

Target Sentence

Glucose-6-phosphate dehydrogenase (G6PD) is a cytosolic enzyme that catalyzes the conversion of glucose-6-phosphate into 6-phosphgluconolactone and maintains the levels of the electron donor, NADPH. G6PD is an x-linked housekeeping gene whose deficiency can result in neonatal jaundice, acute hemolysis, or chronic non-spherocytic hemolytic anemia.

UniGene ID

Hs.684904

UniProt ID (eCommerce)

P11413

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.