human FYCO1 shRNA silencing AAV

Name
AAV-h-FYCO1-shRNA

Cat No
shAAV-209451

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human FYCO1.

shAAV-209451

AAV-h-FYCO1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human FYCO1 (FYVE and coiled-coil domain containing 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CATC2; CTRCT18; FYVE and coiled-coil domain-containing protein 1; RUFY3; RUN and FYVE domain containing 3; ZFYVE7; zinc finger FYVE domain-containing protein 7

Description (eCommerce)

FYCO1 (FYVE and coiled-coil domain-containing protein 1) has been identified as a protein that interacts with LC3, Rab7 and PI3P. FYCO1 contains a FYVE-type zinc finger, one GOLD domain, and a RUN domain. FYCO1 is suggested to play a role in microtubule plus end-directed transport of autophagic vesicles.

Description (Vector)

FYCO1 encodes a protein that contains a RUN domain, FYVE-type zinc finger domain and Golgi dynamics (GOLD) domain. The encoded protein plays a role in microtubule plus end-directed transport of autophagic vesicles through interactions with the small GTPase Rab7, phosphatidylinositol-3-phosphate (PI3P) and the autophagosome marker LC3. Mutations in this gene are a cause of autosomal recessive congenital cataract-2 (CATC2).

Gene ID

79443

Gene Name (eCommerce)

FYVE and coiled-coil domain containing 1

Gene Name (Vector)

FYVE and coiled-coil domain containing 1

Gene Symbol

FYCO1

HGNC ID

HGNC:14673

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

4437

ORF Size (bp)

4437 bp

Protein Name (eCommerce)

FYVE and coiled-coil domain-containing protein 1

RefSeq ID

NM_024513

RefSeq Synonyms

NM_024513, BC101470, BC101468, BC007218,

Research Areas

Autophagy,Lysosome,Transport,Zinc-finger

Research Areas (Faceted)

cell_biology

Species

human

Target Sentence

FYCO1 (FYVE and coiled-coil domain-containing protein 1) has been identified as a protein that interacts with LC3, Rab7 and PI3P. FYCO1 contains a FYVE-type zinc finger, one GOLD domain, and a RUN domain. FYCO1 is suggested to play a role in microtubule plus end-directed transport of autophagic vesicles.

UniGene ID

Hs.714847

UniProt ID (eCommerce)

Q9BQS8

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.