human FXR1 shRNA silencing AAV

Name
AAV-h-FXR1-shRNA

Cat No
shAAV-209437

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human FXR1.

shAAV-209437

AAV-h-FXR1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human FXR1 (FMR1 autosomal homolog 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

80

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

fragile X mental retardation syndrome-related protein 1; fragile X mental retardation, autosomal homolog 1; FXR1P; hFXR1p

Description (eCommerce)

FXR1 (fragile X mental retardation, autonomic homolog 1) is an RNA binding protein that interacts with the functionally-similar proteins FMR1 and FXR2. These proteins shuttle between the nucleus and cytoplasm and associate with polyribosomes, predominantly with the 60S ribosomal subunit [taken from NCBI Entrez Gene (Gene ID: 8087)].

Description (Vector)

FXR1 is an RNA binding protein that interacts with the functionally-similar proteins FMR1 and FXR2. These proteins shuttle between the nucleus and cytoplasm and associate with polyribosomes, predominantly with the 60S ribosomal subunit. Three transcript variants encoding different isoforms have been found for this gene.

Gene ID

8087

Gene Name (eCommerce)

FMR1 autosomal homolog 1

Gene Name (Vector)

FMR1 autosomal homolog 1

Gene Symbol

FXR1

HGNC ID

HGNC:4023

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

1620

ORF Size (bp)

1620 bp

Protein Name (eCommerce)

Fragile X mental retardation syndrome-related protein 1

RefSeq ID

NM_005087

RefSeq Synonyms

NM_005087, NM_001013439, NM_001013438, BC028983,

Research Areas

Apoptosis,mRNA Binding,Neurobiology,RNA Binding,RNA Transport,Translational Control

Research Areas (Faceted)

cell_biology,neurobiology,genetics,transcription_translation

Species

human

Target Sentence

FXR1 (fragile X mental retardation, autonomic homolog 1) is an RNA binding protein that interacts with the functionally-similar proteins FMR1 and FXR2. These proteins shuttle between the nucleus and cytoplasm and associate with polyribosomes, predominantly with the 60S ribosomal subunit [taken from NCBI Entrez Gene (Gene ID: 8087)].

UniGene ID

Hs.478407

UniProt ID (eCommerce)

P51114

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.