human FTH1 shRNA silencing AAV

Name
AAV-h-FTH1-shRNA

Cat No
shAAV-209363

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human FTH1.

shAAV-209363

AAV-h-FTH1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human FTH1 (ferritin heavy chain 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

FHC; FTH; FTHL6; HFE5; PIG15; PLIF

Description (Vector)

FTH1 encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. FTH1 has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined.

Gene ID

2495

Gene Name (Vector)

ferritin heavy chain 1

Gene Symbol

FTH1

HGNC ID

HGNC:3976

ORF Size (aa)

552

RefSeq ID

NM_002032

RefSeq Synonyms

NM_002032, BC104643, BC073750, BC066961, BC066341, BC063514, BC016857, BC016009, BC015156, BC013724, BC011359, BC001399, BC000857,

Species

human

UniGene ID

Hs.645560

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.