human FOXC2 shRNA silencing AAV

Name
AAV-h-FOXC2-shRNA

Cat No
shAAV-209229

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human FOXC2.

shAAV-209229

AAV-h-FOXC2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human FOXC2 (forkhead box C2 (MFH-1, mesenchyme forkhead 1)). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

FKHL14; forkhead box C2 (MFH-1, mesenchyme forkhead 1); forkhead box protein C2; forkhead, Drosophila, homolog-like 14; forkhead-related protein FKHL14; LD; mesenchyme fork head protein 1; mesenchyme forkhead 1; MFH1; MFH-1; MFH-1 protein; MFH-1,mesenchyme forkhead 1; transcription factor FKH-14

Description (eCommerce)

FOXC2 (forkhead box protein C2) is a member of the Forkhead transcription factor family. It is critical to the development of lymphatic vasculture. Mutations in FOXC2 are responsible for lymphedema-distichiasis, a disease characterized by the obstruction of lymphatic drainage of the limbs and extra eyelashes (distichiasis).

Description (Vector)

FOXC2 belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the development of mesenchymal tissues.

Gene ID

2303

Gene Name (eCommerce)

forkhead box C2

Gene Name (Vector)

forkhead box C2 (MFH-1, mesenchyme forkhead 1)

Gene Symbol

FOXC2

HGNC ID

HGNC:3801

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

1506

ORF Size (bp)

1506 bp

Protein Name (eCommerce)

Forkhead box protein C2

RefSeq ID

NM_005251

RefSeq Synonyms

NM_005251, BC113439, BC113437, BC111589,

Research Areas

Cardiac Development,Cardiology,Cardiovascular,Insulin Signaling,Metabolism/Metabolic Process,Neurobiology,Neurodevelopment,Notch Signaling,Signal Transduction,Transcription Factor/Regulator,VEGF Signaling

Research Areas (Faceted)

cardiovascular,cell_biology,developmental_biology,metabolism,neurobiology,signal_transduction,transcription_translation

Species

human

Target Sentence

FOXC2 (forkhead box protein C2) is a member of the Forkhead transcription factor family. It is critical to the development of lymphatic vasculture. Mutations in FOXC2 are responsible for lymphedema-distichiasis, a disease characterized by the obstruction of lymphatic drainage of the limbs and extra eyelashes (distichiasis).

UniGene ID

Hs.436448

UniProt ID (eCommerce)

Q99958

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.