human FKTN shRNA silencing AAV

Name
AAV-h-FKTN-shRNA

Cat No
shAAV-209075

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human FKTN.

shAAV-209075

AAV-h-FKTN-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human FKTN (fukutin). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CMD1X; FCMD; LGMD2M; MDDGA4; MDDGB4; MDDGC4

Description (Vector)

FKTN is a putative transmembrane protein that is localized to the cis-Golgi compartment, where it may be involved in the glycosylation of alpha-dystroglycan in skeletal muscle. The encoded protein is thought to be a glycosyltransferase and could play a role in brain development. Defects in this gene are a cause of Fukuyama-type congenital muscular dystrophy (FCMD), Walker-Warburg syndrome (WWS), limb-girdle muscular dystrophy type 2M (LGMD2M), and dilated cardiomyopathy type 1X (CMD1X). Alternatively spliced transcript variants have been found for this gene.

Gene ID

2218

Gene Name (Vector)

fukutin

Gene Symbol

FKTN

HGNC ID

HGNC:3622

ORF Size (aa)

1386

ORF Size (bp)

1386 bp

RefSeq ID

NM_006731

RefSeq Synonyms

NM_006731, NM_001198963, NM_001079802, BC117700, BC117699, BC112038, BC101808,

Species

human

UniGene ID

Hs.55777

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.