human FKBP1A shRNA silencing AAV

Name
AAV-h-FKBP1A-shRNA

Cat No
shAAV-209057

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human FKBP1A.

shAAV-209057

AAV-h-FKBP1A-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human FKBP1A (FK506 binding protein 1A). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

FKBP-12; FKBP-1A; FKBP1; FKBP12; PKC12; PKCI2; PPIASE

Description (Vector)

FKBP1A is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants, encoding the same protein, have been identified. The human genome contains five pseudogenes related to this gene, at least one of which is transcribed.

Gene ID

2280

Gene Name (Vector)

FK506 binding protein 1A

Gene Symbol

FKBP1A

HGNC ID

HGNC:3711

ORF Size (aa)

438

RefSeq ID

NM_054014

RefSeq Synonyms

NM_054014, NM_001199786, NM_000801, BC119732, BC005147, BC001925,

Species

human

UniGene ID

Hs.700839

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.