human FBXO32 shRNA silencing AAV

Name
AAV-h-FBXO32-shRNA

Cat No
shAAV-208801

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human FBXO32.

shAAV-208801

AAV-h-FBXO32-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human FBXO32 (F-box protein 32). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

Fbx32; MAFbx

Description (Vector)

FBXO32 encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene ID

114907

Gene Name (Vector)

F-box protein 32

Gene Symbol

FBXO32

HGNC ID

HGNC:16731

ORF Size (aa)

633

ORF Size (bp)

633 bp

RefSeq ID

NM_058229

RefSeq Synonyms

NM_148177, NM_058229, NM_001242463, BC120964, BC120963, BC024030,

Species

human

UniGene ID

Hs.403933

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.