human FBL shRNA silencing AAV

Cat. No: shAAV-208733

Availability: 4-5 weeks

Name: AAV-h-FBL-shRNA

This is an AAV expressing shRNA for silencing of Human FBL.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: FBL
Gene Name: fibrillarin
Gene ID: 2091
Gene Synonyms: FIB; FLRN; RNU3IP1
ORF Size: 966 bp
RefSeq#: NM_001436
Gene Description: FBL product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin.
UniGene ID: Hs.299002
HGNC ID: HGNC:3599