human FADD shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human FADD.
shAAV-208257
AAV-h-FADD-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human FADD (Fas associated via death domain). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
GIG3; MORT1
Description (Vector)
FADD is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.
Gene ID
8772
Gene Name (Vector)
Fas associated via death domain
Gene Symbol
FADD
HGNC ID
HGNC:3573
ORF Size (aa)
627
ORF Size (bp)
627 bp
RefSeq ID
NM_003824
RefSeq Synonyms
NM_003824, BC000334,
Species
human
UniGene ID
Hs.86131
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.