human F2RL1 shRNA silencing AAV

Name
AAV-h-F2RL1-shRNA

Cat No
shAAV-208224

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human F2RL1.

shAAV-208224

AAV-h-F2RL1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human F2RL1 (F2R like trypsin receptor 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

GPR11; PAR2

Description (Vector)

Coagulation factor II (thrombin) receptor-like 1 (F2RL1) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL1 is also a member of the protease-activated receptor family. It is activated by trypsin, but not by thrombin. It is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. The F2RL1 gene contains two exons and is widely expressed in human tissues. The predicted protein sequence is 83% identical to the mouse receptor sequence.

Gene ID

2150

Gene Name (Vector)

F2R like trypsin receptor 1

Gene Symbol

F2RL1

HGNC ID

HGNC:3538

ORF Size (aa)

1194

ORF Size (bp)

1194 bp

RefSeq ID

NM_005242

RefSeq Synonyms

NM_005242, BC018130, BC012453,

Species

human

UniGene ID

Hs.154299

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.